Impulsivity Markers in Parkinsonian Subthalamic Single‐Unit Activity

Background Impulsive-compulsive behaviors are common in Parkinson's disease (PD) patients. However, the basal ganglia dysfunctions associated with high impulsivity have not been fully characterized. The objective of this study was to identify features impulsive-compulsive single neurons subthalamic nucleus (STN). Methods We compared temporal and spectral 412 from 12 PD patients 330 without. Single-unit activities were extracted exploratory microrecordings performed during deep brain stimulation (DBS) implant surgery an OFF medication state. Results Patients displayed decreased firing frequency bursts a larger fraction tonic combined weaker beta coherence. Information carried by these led identification accuracy greater than 80%. Conclusions STN © 2021 International Parkinson Movement Disorder Society